Endocrine Abstracts

Introduction: Regulation of adiponectin in GH deficiency (GHD), which presents visceral obesity, is still a matter of debate. No studies have evaluated circulating adiponectin isoforms in adult GHD subjects. Aim of this study was to evaluate total adiponectin (TA) and its isoforms (high molecular weight: HMW, medium molecular weight: MMW, low molecular weight: LMW) in hypopituitary adult subjects with and without GHD, in relation to weight, IGF1 and GH levels.<p class="abs...

The epidemic of obesity and diabetes is increased worldwide, and both are more prevalent in PCOS than non-PCOS ovulatory women. In the general population, the risk of cardiovascular mortality is at least doubled in women with extreme obesity (BMI>40 kg/m2). To explore if PCOS adds further metabolic detriment to extreme obesity, this prospective study compared the metabolic profiles, OGTT-derived insulin sensitivity and body composition between 30 adult PCOS and ...